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The American College of Cardiology stated that millions of Americans should take weight loss drugs to prevent heart disease. When the top American Heart Association issued new recommendations, they said that exercise and a clean diet are not always enough to ensure heart health. The association stated that weight loss drugs should be used early on, making them the first line of defense for obese patients. According to the new guidelines, when choosing the primary treatment for preventing heart disease, consideration should be given to Novo Nordisk's Wegovy and Eli Lilly's Zepbound. This non-profit medical association stated that these popular drugs are more effective than lifestyle changes and carry less risk than surgery. This recommendation is different from their previous one, which advocated for lifestyle changes first before taking weight loss drugs.