The Dow Jones opened down 0.6%, the S&P 500 fell 0.2%, and the Nasdaq fell 0.2%.

Goldman Sachs fell 2.8%, with record high Q1 trading revenue, but bond trading performance was lackluster. Revolution Medicines surged 143.2%, with success in late-stage trial of pancreatic cancer drug. Leggett & Platt rose 8.4%, announcing acquisition agreement with bedding manufacturer Sominigroup. Replimune dropped 63.2%, with FDA rejecting listing application for RP1 again. Best Buy fell 4.3%, with Goldman Sachs downgrading its rating to "sell."