The Dow Jones opened down 0.4%, the S&P 500 down 0.4%, and the Nasdaq down 0.5%.

AstraZeneca rose by 3.5%, with its experimental drug Tezolizumab confirmed to significantly reduce acute exacerbations in patients with chronic obstructive pulmonary disease. Game developer platform Unity Software surged by 18.1%, with Q1 performance exceeding expectations. Argan climbed 16.2%, with both Q4 earnings and revenue surpassing expectations. Travel booking website Tripadvisor increased by 4.8%, as Bank of America upgraded its rating from "Neutral" to "Buy". Southland fell by 28.7%, with a Q4 net loss of $216 million, far exceeding market expectations.