CSPC Innovation Pharmaceutical (300765.SZ) subsidiary SYS6041 has launched Phase II clinical trials.
Shiyao Innovation (300765.SZ) announced that its holding subsidiary Shiyao Group Jushi Biopharmaceutical Co., Ltd. (hereinafter referred to as "Jushi Biopharma") has recently launched an open, multi-cohort, multi-center Phase II clinical trial to evaluate the efficacy and safety of SYS6041 in combination therapy for recurrent ovarian cancer.
CSPC Innovation Pharmaceutical (300765.SZ) announced that its holding subsidiary CSPC PHARMA Giantstone Biopharmaceutical Co., Ltd. (hereinafter referred to as Giantstone Biopharma) has recently launched an open-label, multi-cohort, multi-center Phase II clinical trial to evaluate the efficacy and safety of SYS6041 in combination therapy for recurrent ovarian cancer.
SYS6041 is an antibody-drug conjugate targeting the folate receptor alpha (FR) developed by Giantstone Biopharma. Its antibody can specifically bind to the cell surface expressing FR and is internalized into the cell's lysosome, where it can release small molecule toxinstopoisomerase I inhibitorsthrough specific cleavage by lysosomal proteases, thereby killing tumor cells. It can also exert a bystander effect, non-specifically damaging surrounding tumor tissue cells.
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